What is the Korea Institute of Dermatological Sciences?

All the tests of the Korea Institute of Dermatological Sciences are performed strictly in accordance with
the international standards under internationally accredited SCI study papers, OECD test criteria,
Regulations on Designation etc. of Inspection Agency of Medicines from the Ministry of Food and Drug Safety,
Quasi-drugs, and Cosmetics and Medical Device, medicines clinical trial management criteria, Guidelines
on Human Application Test and Effectiveness Test of Cosmetics, Guidelines on Test Methods for Cosmetics Marking
and Advertisement Demonstration, Guidelines on Effectiveness Test of Functional Cosmetics,
Bioethics and Safety Act by Ministry of Health and Welfare, and Standard Operation Procedure(SOP)
of the Korea Institute of Dermatological Sciences(SOP).

The Korea Institute of Dermatological Sciences is a strict company-oriented research institute that develops safety
and effectiveness evaluations of raw materials and cosmetics through in-vitro cell tests in 2D and 3D and
in vivo human body application tests.

Clinical and efficacy Test

1.Scalp Safety Clinical Test
2.Antioxidant Effect Test
3.Anti-inflammatory Effect Test

1

KIDS BTH001 CBO(2) / Sep. 17, 2020

Scalp Safety (Low Irritation) Human Clinical Test

Human clinical test for evaluation of primary scalp irritation with skin patch of C3 shampoo and hair tonic

The result of 24h skin patch test of C3 Shampoo and Hair Tonic were as follows.
“Any type of irritation was not detected after 30 minutes, 24 hours, and 48 hours removing the patch.” and
“The average skin reactivity was 0.00, which was determined as non-irritating according to the criteria. Accordingly,
all products were certificated as hypoallergenic products”

2

KIDS AOXI02 BZ011 / Dec 24th 2020

Test on Antioxidant Effect

In-vitro Efficacy Test on Antioxidation Effect of Caron Solution

Caron Solution shows DPPH free radical scavenging activity, accordingly it is effective on anti-oxidation. When Caron Solution
is applied with a concentration of 0.1% or less, DPPH free radical scavenging activity is determined to increase by up to
66.2%~66.5% compared to the negative control group. As a DPPH free radical, it is contained in effective oxygen or active oxygen,
and therefore oxidative stress damages skin cells and tissues.

3

KIDS AINF01 BZ011 / Dec 24th 2020

Test on Anti-inflammatory Effect

In-vitro Efficacy Test on Anti-inflammatory Effect of Caron Solution

Caron Solution is effective on anti-inflammatory(inhibits NF-кB activity) by reducing NF-кB activity. When Caron Solution
is applied with a concentration of 0.1%, Intracellular NF-κB activity decreased by 20.5~23.5%.

NF-κB (nuclear factor kappa B) plays an important role in the inflammatory response and causes abnormal development of the immune system

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